生物
细胞生物学
内质网
未折叠蛋白反应
软骨细胞
转录因子
跨膜蛋白
跨膜结构域
亮氨酸拉链
信号转导
高尔基体
受体
软骨
生物化学
解剖
基因
作者
Atsushi Saito,Soshi Kanemoto,Yizhou Zhang,Rie Asada,Kazunori Hino,Kazunori Imaizumi
出处
期刊:Molecular Cell
[Elsevier]
日期:2014-01-01
卷期号:53 (1): 127-139
被引量:43
标识
DOI:10.1016/j.molcel.2013.11.008
摘要
The endoplasmic reticulum (ER) stress transducer BBF2H7/CREB3L2 is an ER-resident transmembrane transcription factor. In response to physiological ER stress, it is processed at the transmembrane region to generate a cytoplasmic N terminus, which contains a basic leucine zipper (bZIP) domain, and luminal C terminus. The BBF2H7 N terminus functions as a transcription factor to promote the expression of ER-Golgi trafficking-related genes and plays crucial roles in chondrocyte differentiation. Here, we found that the BBF2H7 C terminus is secreted into the extracellular space as a signaling molecule for cell-to-cell communication. The secreted BBF2H7 C terminus directly binds to both Indian hedgehog and its receptor Patched-1, followed by activation of Hedgehog signaling, resulting in promoting the proliferation of neighboring chondrocytes. The dual N- and C-terminal functions of BBF2H7 triggered by physiological ER stress may allow chondrocytes to simultaneously regulate distinct cellular events for differentiation and proliferation in developing cartilage.
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