A short, general synthesis of glycerophospholipids

The direct phosphatidylation of 1d-2,3,4,5,6-penta-O-benzyl-myo-inositol with sn-3-phosphatidic acid and subsequent hydrogenolytic debenzylation produces 1d-1-(sn-3-phosphatidyl)-myo-inositol in excellent yield (>90%) and unequivocal structural and stereochemical purity, and, is readily adaptable for large scale production.