医学
美罗华
耐受性
不利影响
内科学
耐火材料(行星科学)
临床试验
痹症科
系统性红斑狼疮
胃肠病学
免疫学
淋巴瘤
天体生物学
物理
疾病
作者
Yoshiya Tanaka,Kazuhiko Yamamoto,Tsutomu Takeuchi,Norihiro Nishimoto,Nobuyuki Miyasaka,Takayuki Sumida,Yoshihito Shima,Kazuki Takada,Isao Matsumoto,Kazuyoshi Saito,Takao Koike
标识
DOI:10.1007/s10165-007-0565-z
摘要
Although corticosteroids and immunosuppressants are widely used for the treatments of systemic lupus erythematosus (SLE), safer and more effective therapies are prerequisite. We and others have reported that anti-CD20 antibody rituximab targeting B cells are effective for refractory SLE and, therefore, safety and clinical efficacy of rituximab in SLE was evaluated by a multicenter phase I/II clinical trial. An open-label, multicenter study of 15 patients with active and refractory SLE (total British Isles Lupus Assessment Group [BILAG] score 8 to 17) was conducted. Rituximab was administered to 5 SLE patients as 4 infusions of 500 mg/body every week and to 10 SLE patients as 2 infusions of 1000 mg/body every other week. Assessment of safety, infusion reactions and adverse effects was used as the primary outcome for clinical tolerability and was evaluated by 28 weeks. Rituximab was well tolerated, with most experiencing no significant adverse effects. B cells rapidly reduced in all patients and remained low until 6 months post-treatment. Four patients developed human antichimeric antibodies without affecting efficacy of rituximab. Changes in routine safety laboratory tests clearly related to rituximab were not observed. Nine among 14 evaluable patients achieved the major or partial clinical response of BILAG score and prednisolone dose significantly decreased at the 28 weeks. Rituximab therapy appears to be safe for the treatment of active SLE patients and holds significant therapeutic promise, at least for the majority of patients experiencing profound B-cell depletion.
科研通智能强力驱动
Strongly Powered by AbleSci AI