Chiral Drugs

ABOUT THE EDITORS vii CONTRIBUTORS ix INTRODUCTION 1 1 OVERVIEW OF CHIRALITY AND CHIRAL DRUGS 3 Guo-Qiang Lin, Jian-Ge Zhang, and Jie-Fei Cheng 2 CHIRAL DRUGS THROUGH ASYMMETRIC SYNTHESIS 29 Guo-Qiang Lin and Xing-Wen Sun 3 CHIRAL DRUGS VIA BIOCATALYTICAL APPROACHES 77 Jianqiang Wang and Wenya Lu 4 RESOLUTION OF CHIRAL DRUGS 137 Qi-Dong You 5 FLUORINE-CONTAINING CHIRAL DRUGS 195 Xiao-Long Qiu, Xuyi Yue, and Feng-Ling Qing 6 INDUSTRIAL APPLICATION OF CHIRAL TECHNOLOGIES 253 Hui-Yin (Harry) Li, Rui Liu, Carl Behrens, and Chao-Ying Ni 7 STRUCTURAL BASIS AND COMPUTATIONAL MODELING OF CHIRAL DRUGS 297 Deping Wang and Eric Hu 8 PHARMACOLOGY OF CHIRAL DRUGS 323 Yongge Liu and Xiao-Hui Gu 9 PHARMACOKINETICS OF CHIRAL DRUGS 347 Hanqing Dong, Xiaochuan Guo and Zengbiao Li 10 TOXICOLOGY OF CHIRAL DRUGS 381 Guang Yang and Hai-Zhi Bu 11 REPRESENTATIVE CHIRAL DRUGS 401 Jiangqin Sun, Dingguo Liu, and Zhimin Wang INDEX 449