骨重建
破骨细胞
成骨细胞
骨吸收
内分泌学
骨质疏松症
碳水化合物代谢
内科学
骨细胞
骨重建期
平衡
生物
医学
生物化学
受体
体外
作者
Courtney M. Karner,Fanxin Long
出处
期刊:Bone
[Elsevier]
日期:2018-10-01
卷期号:115: 2-7
被引量:102
标识
DOI:10.1016/j.bone.2017.08.008
摘要
The adult human skeleton is a multifunctional organ undergoing constant remodeling through the opposing activities of the bone-resorbing osteoclast and the bone-forming osteoblast. The exquisite balance between bone resorption and bone formation is responsible for bone homeostasis in healthy adults. However, evidence has emerged that such a balance is likely disrupted in diabetes where systemic glucose metabolism is dysregulated, resulting in increased bone frailty and osteoporotic fractures. These findings therefore underscore the significance of understanding the role and regulation of glucose metabolism in bone under both normal and pathological conditions. Recent studies have shed new light on the metabolic plasticity and the critical functions of glucose metabolism during osteoclast and osteoblast differentiation. Moreover, these studies have begun to identify intersections between glucose metabolism and the growth factors and transcription factors previously known to regulate osteoblasts and osteoclasts. Here we summarize the current knowledge in the nascent field, and suggest that a fundamental understanding of glucose metabolic pathways in the critical bone cell types may open new avenues for developing novel bone therapeutics.
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