TRPC公司
瞬时受体电位通道
神经科学
TRPC5公司
细胞生物学
生物
伸展激活离子通道
胞吐
离子通道
TRPV公司
电压门控离子通道
受体
内分泌学
生物化学
分泌物
TRPV1型
作者
Sunitha Bollimuntha,Senthil Selvaraj,Brij B. Singh
标识
DOI:10.1007/978-94-007-0265-3_31
摘要
Ca2+ signaling in neurons is intimately associated with the regulation of vital physiological processes including growth, survival and differentiation. In neurons, Ca2+ elicits two major functions. First as a charge carrier, Ca2+ reveals an indispensable role in information relay via membrane depolarization, exocytosis, and the release of neurotransmitters. Second on a global basis, Ca2+ acts as a ubiquitous intracellular messenger to modulate neuronal function. Thus, to mediate Ca2+-dependent physiological events, neurons engage multiple mode of Ca2+ entry through a variety of Ca2+ permeable plasma membrane channels. Here we discuss a subset of specialized Ca2+-permeable non-selective TRPC channels and summarize their physiological and pathological role in the context of excitable cells. TRPC channels are predominately expressed in neuronal cells and are activated through complex mechanisms, including second messengers and store depletion. A growing body of evidence suggests a prime contribution of TRPC channels in regulating fundamental neuronal functions. TRPC channels have been shown to be associated with neuronal development, proliferation and differentiation. In addition, TRPC channels have also been suggested to have a potential role in regulating neurosecretion, long term potentiation, and synaptic plasticity. During the past years, numerous seminal discoveries relating TRPC channels to neurons have constantly emphasized on the significant contribution of this group of ion channels in regulating neuronal function. Here we review the major groundbreaking work that has uniquely placed TRPC channels in a pivotal position for governing neuronal Ca2+ signaling and associated physiological responses.
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