间变性淋巴瘤激酶
病毒癌基因
医学
癌基因
癌症研究
肉瘤
肺癌
淋巴瘤
腺癌
表皮生长因子受体
癌症
激酶
病理
内科学
生物
细胞周期
细胞生物学
恶性胸腔积液
作者
Ping Zhu,Cheng-Hui Li,Hong-Yang Lu
摘要
Abstract
Objective: To analyse clinical and molecular features in patients with surgically resected patients with lung cancer harbouring anaplastic lymphoma kinase fusion.
Methods: The retrospective study was conducted at Zhejiang Cancer Hospital, Hangzhou, China, and comprised data from November 2013 to August 2015 of lung cancer patients. Anaplastic lymphoma kinase, epidermal growth factor receptor, kirsten rat sarcoma viral oncogene, v-raf murine sarcoma viral oncogene homolog, REarranged during Transfection proto-oncogene, c-ros oncogene 1 receptor kinase, V-Erb-B2 avian erythroblastic leukaemia viral oncogene homolog 2 and mesenchymal epithelial transition factor were noted using next generation sequencing. Clinicopathological parameters were also investigated. All patients were followed up till August 10, 2017. Data was analysed using SPSS 22.
Results: Of the 19 patients, 15(79%) were non-smokers. Anaplastic lymphoma kinase rearrangements occurred in the acinar predominant in 6(31.6%), Continuous...
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