钙网蛋白
内质网
癌症研究
细胞
肺癌
化学
CD8型
细胞生物学
免疫原性细胞死亡
免疫学
程序性细胞死亡
细胞凋亡
生物
抗原
免疫疗法
免疫系统
医学
内科学
生物化学
作者
Lili Wang,Ruilin Guan,Lina Xie,Xinxing Liao,Kai Xiong,Thomas W. Rees,Yu Chen,Liang‐Nian Ji,Hui Chao
标识
DOI:10.1002/anie.202013987
摘要
Abstract Immunogenic cell death (ICD) is a vital component of therapeutically induced anti‐tumor immunity. An iridium(III) complex ( Ir1 ), containing an N , N ‐bis(2‐chloroethyl)‐azane derivate, as an endoplasmic reticulum‐localized ICD inducer for non‐small cell lung cancer (NSCLC) is reported. The characteristic discharge of damage‐associated molecular patterns (DAMPs), that is, cell surface exposure of calreticulin (CRT), extracellular exclusion of high mobility group box 1 (HMGB1), and ATP, were generated by Ir1 in A549 lung cancer cells, accompanied by an increase in endoplasmic reticulum stress and reactive oxygen species (ROS). The vaccination of immunocompetent mice with Ir1 ‐treated dying cells elicited an antitumor CD8 + T cell response and Foxp3 + T cell depletion, which eventually resulted in long‐acting anti‐tumor immunity by the activation of ICD in lung cancer cells. Ir1 is the first Ir‐based complex that is capable of developing an immunomodulatory response by immunogenic cell death.
科研通智能强力驱动
Strongly Powered by AbleSci AI