表观基因组
增强子
计算生物学
细胞生物学
图层(电子)
生物
转录因子
DNA甲基化
遗传学
基因
化学
基因表达
有机化学
作者
Vittorio Sartorelli,Shannon Lauberth
标识
DOI:10.1038/s41594-020-0446-0
摘要
Noncoding RNAs (ncRNAs) direct a remarkable number of diverse functions in development and disease through their regulation of transcription, RNA processing and translation. Leading the charge in the RNA revolution is a class of ncRNAs that are synthesized at active enhancers, called enhancer RNAs (eRNAs). Here, we review recent insights into the biogenesis of eRNAs and the mechanisms underlying their multifaceted functions and consider how these findings could inform future investigations into enhancer transcription and eRNA function.
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