双特异性抗体
抗体
髓系白血病
医学
白血病
免疫系统
免疫疗法
髓样
临床试验
免疫学
癌症研究
内科学
抗原
单克隆抗体
作者
Musa Yilmaz,Farhad Ravandi
标识
DOI:10.1016/j.beha.2020.101218
摘要
Bispecific antibodies consist of antigen recognition sites from two or more antibodies redirecting effector immune cell against target on tumor cells. Rapidly evolving medical technologies enabled engineering and development of recombinant protein products, and this, combined with interest from the pharmaceutical industry, further advanced the bispecific antibody research. Over 50 different types of bispecific antibody constructs are now being manufactured and explored in ongoing or future clinical trials. In this review, we will summarize the available data for bispecific antibodies developed and being investigated for the treatment of patients with acute myeloid leukemia.
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