Evaluation of Real Brain Activity Using an Ultracompact Brain Activity Sensor for the Assessment of Cognitive Function

Abstract Background: The present study purpose aims to improve cognitive function at the preclinical stage of dementia and measure real-time brain activity levels in participants wearing an ultracompact brain activity sensor called XB-01. Methods: Four healthy people (two males and two females) aged 20–50 years involved in the dementia prevention program participated in the study. During the experiment, the participants wore XB-01, which was connected to their iPhone by Bluetooth to collect data. XB-01 data indicating the brain activity (blood flow) during the program was demonstrated by real-time color changes on the connected iPhone to evaluate the results on a 100-point scale. We examined 21 programs in total, including those reported to increase brain activity. Results: We conducted an analysis of variance for each of the four programs in the upper and lower positions detected to compare brain activity, resulting in finding a main effect of the program, F(7,21) = 4.35, p <.05. Conclusions: An exercise program including a dual-task with large limb movements was highly effective in increasing brain activity in the dorsolateral prefrontal cortex (DLPFC). Moreover, slightly higher speed, pace, and difficulty level of the program most suitable for participants were more effective. Brain activity increased in the DLPFC during the program and several minutes after its completion. These findings can help develop programs that prevent and improve cognitive function.Trial Registration: The research ethics committee at PCY, Ltd. Trial Registry, approval number 20-2. Registered 04 January 2020. Retrospectively registered.