化学
级联
组合化学
过程(计算)
金属
级联反应
催化作用
纳米技术
试剂
有机化学
计算机科学
色谱法
操作系统
材料科学
作者
Kai Wei,Yu-Cui Sun,Rui Li,Jing-Feng Zhao,Wen Chen,Hongbin Zhang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-08-18
卷期号:23 (17): 6669-6673
被引量:2
标识
DOI:10.1021/acs.orglett.1c02234
摘要
Herein, we report a new process for the synthesis of highly functionalized pyridines based on a tandem Pummerer-type rearrangement, aza-Prins cyclization, and elimination-induced aromatization. This formal [5+1] cyclization provides pyridines in good yields with easily accessible starting materials. The synthetic potential of our new method is further demonstrated in the modification of the frameworks of BINOL and some natural products.
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