透皮
角质层
自愈水凝胶
化学
药理学
药物输送
CD86
T细胞
医学
免疫系统
免疫学
病理
高分子化学
有机化学
作者
Chengxiao Wang,Shengnan Liu,Jun‐Wei Xu,Mingju Gao,Yuan Qu,Yuan Liu,Ye Yang,Xiuming Cui
标识
DOI:10.1016/j.carbpol.2021.118211
摘要
This work explored the feasibility of using biological polysaccharide to fabricate dissolvable microneedles (MNs) for the purpose of transdermal drug delivery and skin dendritic cell (DC) activation. Panax notoginseng polysaccharide (PNPS), a naturally derived immunoactive macromolecule, was used to fabricate dissolvable MNs. The prepared PNPS MNs showed a satisfactory mechanical strength and a skin penetration depth. By Franz diffusion cell assay, the PNPS MNs demonstrated a high transdermal delivery amount of model drugs. Furthermore, with the assistance of MNs, PNPS easily penetrated across the stratum corneum and target ear skin DCs, activating the maturation and migration of immunocytes by increasing the expressions of CD40, CD80, CD86, and MHC II of skin DCs. Consequently, the matured DCs migrated to the auricular draining lymph nodes and increased the proportions of CD4+ T and CD8+ T cells. Thus, PNPS might be a promising biomaterial for transdermal drug delivery, with adjuvant potential.
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