Ionic wind technology as a potential substitute for traditional heat dissipation technology has attracted great attention. In this study, two types of multistage ionic wind heat sink using needle-mesh electrodes were studied. The relationship between the number of needles, the number of stages, and the coefficient k is determined through numerical calculation, and the cooling performance of the two different structures is tested and quantitatively analyzed. The results show that, compared with the single-stage ionic wind heat sink, the cooling performance of multistage ionic wind heat sink has been greatly improved. The maximum enhancement factor is 3.705. The integrated multistage ionic wind heat sink was proposed for the first time. The integrated multistage ionic wind heat sink can achieve better cooling performance under lower working voltage. The volume of integrated structure has been reduced by more than 60%.