横纹肌溶解症
急性肾损伤
医学
肌红蛋白
药理学
内科学
化学
生物化学
作者
Katsuyuki Matsushita,Kiyoshi Mori,Turgay Saritas,Mahaba B. Eiwaz,Y. Funahashi,Megan N. Nickerson,Jessica F. Hebert,Adam C. Munhall,James A. McCormick,Motoko Yanagita,Michael P. Hutchens
出处
期刊:Journal of The American Society of Nephrology
日期:2021-08-02
卷期号:32 (10): 2579-2594
被引量:55
标识
DOI:10.1681/asn.2020030263
摘要
We conclude that megalin plays a critical role in rhabdomyolysis-induced AKI, and megalin interference and inhibition ameliorate rhabdomyolysis-induced AKI. Further investigation of megalin inhibition may inform translational investigation of a novel potential therapy.
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