医学
卡铂
剜除术
不利影响
眼科
视网膜母细胞瘤
冷冻疗法
外科
内科学
化疗
顺铂
生物化学
基因
化学
作者
Benjamin King,Matthew W. Wilson,Tracy Kaluzny,Carly Meredith,Julie Overbey-Canon,Jason Chiang,Rachel C. Brennan
标识
DOI:10.1016/j.oret.2022.11.003
摘要
To determine the safety and toxicity profile of intravitreal carboplatin as salvage treatment for retinoblastoma with vitreous disease.Single-institution, interventional prospective clinical trial.Patients with progressive or recurrent vitreous seeds after completion of primary treatment for intraocular retinoblastoma.Eligible eyes received an intravitreal injection of carboplatin every 14 to 21 days with simultaneous focal therapy (laser, thermotherapy, and brachytherapy) provided at the discretion of the ocular oncologist. The evaluation with examination under anesthesia, ultrasound biomicroscopy, and electroretinography (ERG) were performed before each injection to assess for tumor response and drug-related toxicity. A serious adverse event resulted in dose recalculation and ultimately early closure of the study.Regression pattern of vitreous disease and incidence of dose-limiting toxicities.Four patients were enrolled at an initial dose of 0.3 mg. Complete regression of vitreous seeds was noted in all patients after 5, 2, 2, and 1 injections (respectively). Two patients developed recurrent vitreous disease at 3 and 25 months after complete regression and ultimately required enucleation. A serious adverse event occurred in 1 patient who developed acute vision loss with extinguished ERG response 72 hours after the second injection; ultimately, this eye developed a cataract and required enucleation. After temporary suspension and dose modification, 3 patients were enrolled at an injection dose of 3 μg and treated with a total of 5, 2, and 1 injections, respectively. Complete regression of vitreous disease was not achieved in any patient though ERG amplitudes remained stable. After removal from protocol, all 3 patients had a complete response to intravitreal melphalan. Concern for dose escalation and further toxicity in the setting of an effective and safe alternative (melphalan) led to the termination of the study.Intravitreal carboplatin may be effective in treating progressive vitreous seeding at higher doses, but permanent retinal toxicity was observed. Other alternative agents should be considered.Proprietary or commercial disclosure may be found after the references.
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