医学
比例危险模型
滑膜肉瘤
单变量分析
阶段(地层学)
外科
肉瘤
肿瘤科
内科学
多元分析
病理
古生物学
生物
作者
Yi Jin,Xiaoyang Li,Shichong Yu
出处
期刊:Heliyon
[Elsevier]
日期:2024-01-01
卷期号:10 (1): e23437-e23437
标识
DOI:10.1016/j.heliyon.2023.e23437
摘要
BackgroundThis investigation studied the clinical features and outcomes of synovial sarcoma (SS) patients from a single institution.MethodsA retrospective clinicopathologic study was conducted on 129 postoperative SS patients during 2003–2018. Kaplan-Meier curves and Cox proportional hazards regression (Cox) models were performed to determine the parameters associated with recurrence-free survival (RFS), metastasis-free survival (MFS), and cancer-specific survival (CSS) via univariate and multivariate analysis. The impact of unplanned excision (UE) and residual tumor in re-excision specimens was evaluated.ResultsThe 3-year RFS, MFS and 5-year CSS were 72 %, 70 %, and 76 %, respectively. Independent factors associated with significantly inferior survival included older age, UE without re-excision, UE with residual tumors, high grade, and deep tumor for RFS, trunk-related tumor, UE without re-excision, UE with residual tumors, and deep tumor for MFS, UE with residual tumors, high grade, and deep tumor for CSS. Re-excision after UE was significantly associated with better RFS (P < 0.001). Residual tumors were remarkably correlated with inferior RFS (P = 0.0012), MFS (P = 0.0016), and CSS (P = 0.048), especially in patients at stage II (MFS: P < 0.001, CSS: P = 0.0014).ConclusionUE and residual tumors have a marked impact on the long-term survival of SS patients. Primary wide excision and re-excision is especially essential for patients at stage II.
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