转录因子II F
转录因子ⅡE
RNA聚合酶Ⅱ
转录前起始复合物
调解人
转录因子ⅡD
生物
抄写(语言学)
一般转录因子
真核转录
RNA聚合酶Ⅱ全酶
细胞生物学
蛋白质亚单位
计算生物学
发起人
遗传学
转录调控
转录因子
基因
基因表达
语言学
哲学
作者
Santiago Nicolás Freytes,María Laura Gobbini,Pablo D. Cerdán
标识
DOI:10.1146/annurev-arplant-070623-114005
摘要
Thirty years have passed since the discovery of the Mediator complex in yeast. We are witnessing breakthroughs and advances that have led to high-resolution structural models of yeast and mammalian Mediators in the preinitiation complex, showing how it is assembled and how it positions the RNA polymerase II and its C-terminal domain (CTD) to facilitate the CTD phosphorylation that initiates transcription. This information may be also used to guide future plant research on the mechanisms of Mediator transcriptional control. Here, we review what we know about the subunit composition and structure of plant Mediators, the roles of the individual subunits and the genetic analyses that pioneered Mediator research, and how transcription factors recruit Mediators to regulatory regions adjoining promoters. What emerges from the research is a Mediator that regulates transcription activity and recruits hormonal signaling modules and histone-modifying activities to set up an off or on transcriptional state that recruits general transcription factors for preinitiation complex assembly. Expected final online publication date for the Annual Review of Plant Biology, Volume 75 is May 2024. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
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