NF-κB
炎症
NFKB1型
医学
炎症反应
艾地苯醌
药理学
全身炎症反应综合征
免疫学
化学
败血症
生物化学
转录因子
基因
作者
Yumin Choi,Young‐Lai Cho,S H Park,Min-Kyung Park,Keun-Seok Hong,Young-Jun Park,Inah Lee,Sung Min Chung,Heedoo Lee,Seon-Jin Lee
出处
期刊:Antioxidants
[MDPI AG]
日期:2024-01-25
卷期号:13 (2): 151-151
标识
DOI:10.3390/antiox13020151
摘要
Inflammation is a natural protective process through which the immune system responds to injury, infection, or irritation. However, hyperinflammation or long-term inflammatory responses can cause various inflammatory diseases. Although idebenone was initially developed for the treatment of cognitive impairment and dementia, it is currently used to treat various diseases. However, its anti-inflammatory effects and regulatory functions in inflammatory diseases are yet to be elucidated. Therefore, this study aimed to investigate the anti-inflammatory effects of idebenone in cecal ligation puncture-induced sepsis and lipopolysaccharide-induced systemic inflammation. Murine models of cecal ligation puncture-induced sepsis and lipopolysaccharide-induced systemic inflammation were generated, followed by treatment with various concentrations of idebenone. Additionally, lipopolysaccharide-stimulated macrophages were treated with idebenone to elucidate its anti-inflammatory effects at the cellular level. Idebenone treatment significantly improved survival rate, protected against tissue damage, and decreased the expression of inflammatory enzymes and cytokines in mice models of sepsis and systemic inflammation. Additionally, idebenone treatment suppressed inflammatory responses in macrophages, inhibited the NF-κB signaling pathway, reduced reactive oxygen species and lipid peroxidation, and normalized the activities of antioxidant enzyme. Idebenone possesses potential therapeutic application as a novel anti-inflammatory agent in systemic inflammatory diseases and sepsis.
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