巨噬细胞极化
巨噬细胞
免疫系统
肿瘤微环境
肿瘤进展
生物
功能(生物学)
细胞生物学
癌症研究
免疫
刺激
肿瘤相关巨噬细胞
癌症
免疫学
神经科学
生物化学
体外
遗传学
作者
Hilda L. Chan,Xiang H.-F. Zhang
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:2024-01-19
标识
DOI:10.1158/0008-5472.can-24-0201
摘要
Macrophages are plastic immune cells that have varying functions dependent on stimulation from their environment. In a recent issue of Immunity, Do and colleagues demonstrated that activating mechanistic target of rapamycin complex 1 signaling in tumor macrophages alters their metabolism, localization, and function. Specifically, these tumor macrophages promote vascular remodeling that develops a hypoxic environment toxic to cancer cells. This culminates in a tangible reduction in tumor burden in a murine model of breast cancer. Their findings reveal a unique strategy to promote vascular remodeling through macrophage polarization and thereby highlight the intimate connections between macrophage metabolism and function. Additionally, their model highlights parallels between tumor progression and wound healing contexts while emphasizing the amplified effect of small perturbations to a tumor ecosystem.
科研通智能强力驱动
Strongly Powered by AbleSci AI