冲程(发动机)
神经科学
医学
内科学
心理学
物理
热力学
作者
Taotao Jiang,Tao Zheng,Rundong Li,Jingjing Sun,X. Luan,Manxia Wang
出处
期刊:Neuropeptides
[Elsevier]
日期:2024-04-01
卷期号:104: 102412-102412
标识
DOI:10.1016/j.npep.2024.102412
摘要
Neuropeptide Y (NPY), an extensively distributed neurotransmitter within the central nervous system (CNS), was initially detected and isolated from the brain of a pig in 1982. By binding to its G protein-coupled receptors, NPY regulates immune responses and contributes to the pathogenesis of numerous inflammatory diseases. The hippocampus contained the maximum concentration in the CNS, with the cerebral cortex, hypothalamus, thalamus, brainstem, and cerebellum following suit. This arrangement suggests that the substance has a specific function within the CNS. More and more studies have shown that NPY is involved in the physiological and pathological mechanism of stroke, and its serum concentration can be one of the specific biomarkers of stroke and related complications because of its high activity, broad and complex effects. By summarizing relevant literature, this article aims to gain a thorough understanding of the potential clinical applications of NPY in the treatment of stroke, identification of stroke and its related complications, and assessment of prognosis.
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