卤化
区域选择性
化学
组合化学
芳基
药物化学
有机化学
催化作用
烷基
作者
Vaibhav D. Prajapati,Ronak V. Prajapati,Vishal B. Purohit,Jemin R. Avalani,Nirav H. Sapariya,Ronak D. Kamani,Sharad C. Karad,Dipak K. Raval
标识
DOI:10.1002/slct.202204126
摘要
Abstract A simple and efficient strategy for N‐chlorosuccinimide mediated regioselective C−H sulfenylation and halogenation of 4 H ‐pyrido[1,2‐ a ]pyrimidin‐4‐ones has been established at room temperature using aryl thiols and phenyliodine(III) diacetate (PIDA) respectively. This methodology tolerated a broad variety of functional groups to obtain structurally diverse sulfenyl and halogenated 4 H ‐pyrido[1,2‐a]pyrimidin‐4‐one derivatives under mild conditions. It delivered a range of products which can serve as the key precursors for the synthesis of complex products relevant to pharmaceutical applications.
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