Nanoemulsions Challenges and Future Prospects as a Drug Delivery System

Nanoemulsion during the recent years proved that has the potential to overwhelm numerous difficulties in formulation of drugs. By loading drugs with poor water-solubility in the proper nanoemulsions improves their solubility and/or wettability. Therefore, this expands their pharmacodynamics as well as pharmacokinetics by diverse administration methods. Accompanying with the optimal size of nanodroplets, the droplets act as a drugs pool, facilitating nanoemulsion to do as a multifunctional platform to defect different diseases. A number of significant advantages, which include nanoemulsion qualities, such as well-organized drug release with suitable rate, extended efficacy, control of drug uptake, the ability of drug protection from oxidation and low side effects, have been described in last decades. The great characteristic of nanoemulsion contains also a diversity of engineering procedure options as well as a combination of extensively mixed components such as liquid lipids, surfactants or even drug-conjugates. These structures afford alternatives for designing advanced nanoemulsions pointing at high-value and different applications. This review presents the challenges and prospects of diverse nanoemulsion types and its application as drug delivery methods. Types of nanoemulsions as well as components of a nanoemulsions, their manufacturing via different methods like (High pressure homogenization, Ultrasonication, Microfluidization, Phase Inversion, Temperature Spontaneous Emulsification, Membrane Emulsification, Emulsion Inversion Point) is described. Different drug delivery applications (Oral, Parenteral, Transdermal, Topical, Intranasal and Ocular delivery) is presented. Kinetics of drug release as well as stability of nanoemulsions are also presented.