42364 MRPGRX2 Antagonist EP262 Prevents Inflammation and Disease in a Mouse Model of Atopic Dermatitis

Rationale: Mast cells are shown to play a role in multiple inflammatory diseases including atopic dermatitis. Mas-Related G-Protein Coupled Receptor X2 (MRGPRX2) is a promiscuous receptor on mast cells that mediates IgE-independent mast cell activation and degranulation in response to a wide variety of structurally diverse compounds and has been implicated in mast cell-mediated conditions. Our objective was to investigate whether small molecule MRGPRX2 antagonist EP262 could improve disease phenotype in the house dust mite (HDM)/ Staphylococcus aureus enterotoxin type B (SEB) mouse model of atopic dermatitis.