Predicting 10‐year risk of type 2 diabetes in Chinese people with overweight or obesity treated with Tirzepatide: Post hoc analysis of SURMOUNT ‐ CN trial

Abstract Aim To assess the association of tirzepatide use with a 10‐year predicted risk of type 2 diabetes (T2D) among Chinese participants with obesity or overweight from the SURMOUNT‐CN trial. Materials and Methods In this post hoc analysis, the QDiabetes‐2018 risk engine was used to calculate the 10‐year predicted T2D risk at baseline, week 24 and week 52 among SURMOUNT‐CN participants randomized to receive tirzepatide 10 mg, 15 mg or placebo. A mixed model for repeated measures was used to compare mean predicted risk changes from baseline to weeks 24 and 52 between tirzepatide and placebo. Subgroup analyses were conducted by baseline body weight mass index (BMI) status and baseline prediabetes status. Results Demographic and baseline clinical characteristics were similar among tirzepatide10 mg ( n = 59), 15 mg ( n = 53) and placebo ( n = 57). From baseline to week 52, the least square (LS) mean predicted T2D risk changed from 5.3% to 1.2% for tirzepatide 10 mg, from 4.9% to 1.0% for tirzepatide 15 mg and from 5.8% to 4.5% for placebo. The difference in LS mean risk change from baseline to week 52 was significant between both tirzepatide 10 mg (−3.2%, 95% confidence interval [CI]: −4.2%, −2.2%) and 15 mg (−3.4%, 95% CI: −4.4%, −2.4%) and placebo. Significantly greater predicted risk reductions for tirzepatide than placebo were observed in all subgroups. Conclusion Tirzepatide was associated with significantly reduced predicted 10‐year risk of T2D among SURMOUNT‐CN participants with obesity or overweight, irrespective of baseline BMI and prediabetes status.