表面等离子共振
胶体金
材料科学
等离子体子
纳米技术
基质(水族馆)
连接器
纳米颗粒
红移
光电子学
物理
海洋学
地质学
操作系统
银河系
量子力学
计算机科学
作者
Jacob Waitkus,Yu Wei Chang,Li Liu,Srinivasu Valagerahally Puttaswamy,Taerin Chung,Adrian M. Molina Vargas,Stephen J. Dollery,Mitchell R. O’Connell,Haogang Cai,Gregory J. Tobin,Nikhil Bhalla,Ke Du
标识
DOI:10.1002/admi.202201261
摘要
A novel localized surface plasmon resonance (LSPR) system based on the coupling of gold nanomushrooms (AuNMs) and gold nanoparticles (AuNPs) is developed to enable a significant plasmonic resonant shift. The AuNP size, surface chemistry, and concentration are characterized to maximize the LSPR effect. A 31 nm redshift is achieved when the AuNMs are saturated by the AuNPs. This giant redshift also increases the full width of the spectrum and is explained by the 3D finite-difference time-domain (FDTD) calculation. In addition, this LSPR substrate is packaged in a microfluidic cell and integrated with a CRISPR-Cas13a RNA detection assay for the detection of the SARS-CoV-2 RNA targets. Once activated by the target, the AuNPs are cleaved from linker probes and randomly deposited on the AuNM substrate, demonstrating a large redshift. The novel LSPR chip using AuNP as an indicator is simple, specific, isothermal, and label-free; and thus, provides a new opportunity to achieve the next generation multiplexing and sensitive molecular diagnostic system.
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