Preparation of Metal Nanocluster Supraparticles for Ultrasensitive Sensing of Tetracycline Based on Multiple Interactions between a Target and Sensor

ions, and the quantum yield reached 69.1%. Moreover, we found that tetracycline (TC) could bind to the Sc-CB/AuNCs through simultaneous host-guest recognition and ionic complexation, which effectively quenched the Sc-CB/AuNCs through the synergy of photoinduced electron transfer and inner filter effect. Based on the above multiple interactions between TC and Sc-CB/AuNCs, an ultrasensitive sensing method for TC was constructed with an LOD of 0.3 nM. Furthermore, a portable fluorescent gel sensor was constructed and successfully used for TC detection in honey samples. The test took only 2 min. This work not only provided a simple and effective fluorescence enhancement strategy for MNCs but also offered a novel sensing strategy, which may largely extend the potential of host-guest recognition-based sensors for food and environmental hazards.