PI3K/AKT/mTOR通路
癌症研究
蛋白激酶B
对氧磷酶
细胞
癌基因
细胞生长
转移
生物
基底细胞
细胞周期
癌症
医学
内科学
信号转导
细胞生物学
内分泌学
遗传学
氧化应激
作者
Lili Zhu,Yiyin Shen,Wei Sun
标识
DOI:10.1016/j.biopha.2016.11.084
摘要
Paraoxonase 3 (PON3) is an oncogene in cancer, however, little is known about the mechanisms and roles of PON3 in oral squamous cell carcinoma (OSCC), which is the aim of our study. We found that the expression of PON3 was up-regulated in OSCC samples and cell lines. PON3 was associated with accelerating cell proliferation, cell cycle, migration and invasion in OSCC cells. Further research showed that PON3 was regulated by PI3K/Akt pathway. We also found that AP-1 was an important transcriptional factor regulating PON3 expression in OSCC. The study elucidates that PI3K/Akt pathway up-regulated the expression of PON3 in OSCC by AP-1.
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