Synthesis of Chiral 2-OXO- and 2-THIO-1,3,2-Oxazaphospholidines via the Asymmetric Cyclization of L-Serinoates with (Thio)Phosphoryl Dichlorides

Abstract In this paper is described the asymmetric cyclization of L-serine derivatives with phosphoro(no-)dichloridates or their thio-analogues, and investigated the asymmetric induction effect of chiral carbon centre on the forming chiral phosphorus centre. Some cyclization products have been separated as a pure diastereomer and their configuration is preliminarily discussed.