化学
全合成
奎尼嗪
炔丙醇
非对映体
醛
炔丙基
双环分子
生物碱
酒
立体化学
骨架(计算机编程)
有机化学
组合化学
程序设计语言
催化作用
计算机科学
作者
Sok Teng Tong,David Barker
标识
DOI:10.1016/j.tetlet.2006.05.092
摘要
A total synthesis of the quinolizidine alkaloid (+)-epiquinamide 1 has been achieved starting from (−)-pipecolinic acid 3. The key step is the highly diastereoselective addition of a TBDMS-protected propargyl alcohol to a chiral aldehyde derived from 3 to give erythro alkynol 19, which is then easily transformed into the desired bicyclic skeleton.
科研通智能强力驱动
Strongly Powered by AbleSci AI