Design of the First-in-Human Study of IONIS-MAPTRx, a Tau-lowering Antisense Oligonucleotide, in Patients With Alzheimer Disease (S2.006)
医学
老年学
内科学
疾病
作者
Laurence Mignon,Holly Kordasiewicz,Roger Lane,Anne Smith,Timothy M. Miller,Padma Kumar Narayanan,Eric E. Swayze,Daniel A. Norris,Bethany Fitzsimmons,Frank Bennett
出处
期刊：Neurology [Lippincott Williams & Wilkins] 日期：2018-04-10卷期号：90 (15_supplement)被引量：25
To design a study to test IONIS-MAPTRx an antisense oligonucleotide (ASO) developed to specifically, potently and safely reduce MAPT mRNA in patients with tauopathies.
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