Process Control and Intensification of Solution Crystallization

Solution crystallization attracts more and more attention in the pharmaceutical industries because of the functions of separation and the tuning ability of solid-state properties at the molecular level. Generally, the research of solution crystallization includes crystal engineering and crystallization process design and control. The crystallization process design and control have achieved great progress in the past decade, in which process analytical technology (PAT) has come to the real manufacturing practice and the conversion from batch to continuous is becoming a clear tendency. In this chapter, the design and optimization of the crystallization process are summarized that covers process control, seeding technique, intensification by external fields, and the solution crystallization in continuous manufacturing.