医学
前列腺癌
骨闪烁照相术
核医学
放射科
荟萃分析
PET-CT
出处
期刊:American Journal of Roentgenology
[American Roentgen Ray Society]
日期:2022-04-20
摘要
Background: Bone scintigraphy (BS) using 99mTc-MDP remains the recommended imaging modality for the detection of bone metastases in patients with prostate cancer (PCa). However, PET/CT using prostate-specific membrane antigen (PSMA) ligands is increasingly recognized for evaluating disease extent in patients with PCa, including as a possible standalone test in high-risk patients. Objective: To compare the diagnostic performance of 68Ga-PSMA-PET/CT and 99mTc-MDP BS for the detection of bone metastases in patients with PCa. Evidence Acquisition: PubMed, Embase, and Cochrane Library databases were searched through October 2021 for studies reporting a head-to-head comparison of 68Ga-PSMA-PET/CT and 99mTc-MDP BS for the detection of bone metastases in patients with PCa. Only studies with a well-defined reference standard (including various combinations of imaging and/or clinical follow-up) were included. Pooled diagnostic performance was calculated using bivariate random-effects model, and AUC was derived for each test from hierarchical summary ROC analysis. The two tests' complementary roles in identifying bone metastases in patients in whom the other test was negative were summarized. Evidence Synthesis: Six studies with 546 patients were included. The pooled sensitivity and specificity were 98% (95% CI: 94%-99%) and 97% (95% CI: 91%-99%) for 68Ga-PSMA-11 PET/CT versus 83% (95% CI: 69%-91%) and 68% (95% CI: 41%-87%) for 99mTc-MDP BS. The AUC was 0.99 (95% CI: 0.96-1.00) for 68Ga-PSMA-11 PET/CT and 0.85 (95% CI: 0.81-0.87) for 99mTc-MDP BS. In 408 patients from five included studies, 68Ga-PSMA-11 PET/CT correctly identified bone metastases in 43 (22.3%) of 193 patients with negative 99mTc-MDP BS results, whereas 99mTc-MDP BS correctly identified bone metastases in 4 (1.9%) of 210 patients with negative 68Ga-PSMA-11 PET/CT results. Conclusion: On a per-patient basis, 68Ga-PSMA-11 PET/CT has superior diagnostic performance than 99mTc-MDP BS for the detection of prostate cancer bone metastases. Furthermore, 99mTc-MDP BS offers limited additional information in patients with negative 68Ga-PSMA-11 PET/CT results. Clinical impact: According to current evidence, 99mTc-MDP BS is highly unlikely to be additive to 68Ga-PSMA-11 PET/CT in identifying bone metastases in patients with prostate cancer.
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