动脉瘤
大脑中动脉
数字减影血管造影
医学
血管造影
放射科
逻辑回归
分叉
女儿
心脏病学
统计显著性
脑血管造影
内科学
作者
Jian Zhang,Anil Can,Pui Man Rosalind Lai,Srinivasan Mukundan,Victor M. Castro,Dmitriy Dligach,Sean Finan,Vivian S. Gainer,Nancy A. Shadick,Guergana Savova,Shawn N. Murphy,Tianxi Cai,Scott T. Weiss,Rose Du
标识
DOI:10.1016/j.jstrokecerebrovasdis.2021.106268
摘要
Abstract
Objectives
The pathogenesis of intracranial aneurysms is multifactorial and includes genetic, environmental, and anatomic influences. We aimed to identify image-based morphological parameters that were associated with middle cerebral artery (MCA) bifurcation aneurysms. Materials and methods
We evaluated three-dimensional morphological parameters obtained from CT angiography (CTA) or digital subtraction angiography (DSA) from 317 patients with unilateral MCA bifurcation aneurysms diagnosed at the Brigham and Women's Hospital and Massachusetts General Hospital between 1990 and 2016. We chose the contralateral unaffected MCA bifurcation as the control group, in order to control for genetic and environmental risk factors. Diameters and angles of surrounding parent and daughter vessels of 634 MCAs were examined. Results
Univariable and multivariable statistical analyses were performed to determine statistical significance. Sensitivity analyses with smaller (≤ 3 mm) aneurysms only and with angles excluded, were also performed. In a multivariable conditional logistic regression model we showed that smaller diameter size ratio (OR 0.0004, 95% CI 0.0001–0.15), larger daughter-daughter angles (OR 1.08, 95% CI 1.06–1.11) and larger parent-daughter angle ratios (OR 4.24, 95% CI 1.77–10.16) were significantly associated with MCA aneurysm presence after correcting for other variables. In order to account for possible changes to the vasculature by the aneurysm, a subgroup analysis of small aneurysms (≤ 3 mm) was performed and showed that the results were similar. Conclusions
Easily measurable morphological parameters of the surrounding vasculature of the MCA may provide objective metrics to assess MCA aneurysm formation risk in high-risk patients.
科研通智能强力驱动
Strongly Powered by AbleSci AI