体内分布
体内
纳米颗粒
氧化铁纳米粒子
癌症
细胞毒性
化学
癌细胞
氧化铁
生物物理学
癌症治疗
纳米技术
癌症研究
材料科学
体外
生物化学
医学
内科学
生物
有机化学
生物技术
作者
Xiangrong Tian,Li Ruan,Shengwang Zhou,Lin Wu,Jin Cao,Xueyong Qi,Xin Zhang,Song Shen
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2022-03-17
卷期号:5 (4): 1692-1699
被引量:19
标识
DOI:10.1021/acsabm.2c00068
摘要
Iron oxide nanoparticles can induce cell death due to the ferroptosis mechanism, showing a great potential for cancer therapy. Here, we synthesized different-sized iron oxide nanoparticles (2-100 nm) to investigate their antitumor effect and toxicity mechanism. It was found that ultrasmall nanoparticles (< ∼5 nm) could accumulate in nucleus and were more efficient in triggering the generation of •OH than larger nanoparticles due to the quicker release of Fe2+, thus exhibiting more remarkable cytotoxicity. Nevertheless, 10 nm iron oxide nanoparticles group displayed the best antitumor effect in vivo. We studied the in vivo and intratumoral biodistribution of the nanoparticles and found that the therapeutic effects were related to both the tumoral accumulation and intratumoral distribution of nanoparticles. This work indicates the appropriate size of Fe3O4 NPs for cancer treatment and illustrates the possible factors that influence the therapeutic effect, suggesting the great potential of iron oxide in clinical application.
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