化学
废止
分子内力
羟醛反应
全合成
戒指(化学)
立体选择性
立体化学
天然产物
环闭合复分解
复分解
盐变质反应
有机化学
催化作用
聚合
聚合物
作者
Marc Paul Beller,Sergei I. Ivlev,Ulrich Koert
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-01-18
卷期号:24 (3): 912-915
被引量:5
标识
DOI:10.1021/acs.orglett.1c04261
摘要
A stereoselective synthesis of the proposed and actual structures of the natural products preussochromones E and F is reported. The key step is a ring-closing metathesis to close the five-membered ring and install the trans configuration of the annulated five-six ring system. The analysis of the 3J NMR couplings of the isolated natural product with the synthesized compound revealed its real structure with a cis annulation, which could also be synthesized using an intramolecular aldol reaction of a vic-tricarbonyl compound.
科研通智能强力驱动
Strongly Powered by AbleSci AI