磁刺激
多发性硬化
运动皮层
医学
初级运动皮层
沉默期
刺激
物理医学与康复
诱发电位
神经科学
心理学
听力学
内科学
精神科
作者
Joachim Liepert,D Mingers,Christoph Heesen,Tobias Bäumer,Cornelius Weiller
标识
DOI:10.1191/1352458505ms1163oa
摘要
We investigated electrophysiological correlates of fatigue in patients with multiple sclerosis (MS). Transcranial magnetic stimulation (TMS) was used to explore motor excitability in three groups of subjects: MS patients with fatigue (MS-F), MS patients without fatigue (MS-NF) and healthy control subjects. All participants had to perform a fatiguing hand-grip exercise. TMS was performed prior to and after the exercise. Prior to the motor task, MS-F patients had less inhibition in the primary motor cortex compared to both other groups. Postexercise, intracortical inhibition was still reduced in the MS-F patients compared to the MS-NF patients. In MS-F patients the postexercise time interval for normalization of the motor threshold was correlated with the fatigue severity. We conclude that MS patients with fatigue have an impairment of inhibitory circuits in their primary motor cortex. The results also indicate that fatigue severity is associated with an exercise-induced reduction of membrane excitability.
科研通智能强力驱动
Strongly Powered by AbleSci AI