医学
磁共振成像
克罗恩病
放射科
分级(工程)
核医学
脑脊液
病理
疾病
工程类
土木工程
作者
Shonit Punwani,Manuel Rodríguez-Justo,Alan Bainbridge,Rebecca Greenhalgh,Enrico De Vita,Stuart Bloom,Richard Cohen,Alastair Windsor,Austin Obichere,Anika Hansmann,Marco Novelli,Steve Halligan,Stuart A. Taylor
出处
期刊:Radiology
[Radiological Society of North America]
日期:2009-09-01
卷期号:252 (3): 712-720
被引量:232
标识
DOI:10.1148/radiol.2523082167
摘要
Purpose To validate proposed magnetic resonance (MR) imaging features of Crohn disease activity against a histopathologic reference. Materials and Methods Ethical permission was given by the University College London hospital ethics committee, and informed written consent was obtained from all participants. Preoperative MR imaging was performed in 18 consecutive patients with Crohn disease undergoing elective small-bowel resection. The Harvey-Bradshaw index, the C-reactive protein level, and disease chronicity were recorded. The resected bowel was retrospectively identified at preoperative MR imaging, and wall thickness, mural and lymph node/cerebrospinal fluid (CSF) signal intensity ratios on T2-weighted fat-saturated images, gadolinium-based contrast material uptake, enhancement pattern, and mesenteric signal intensity on T2-weighted fat-saturated images were recorded. Precise histologic matching was achieved by imaging the ex vivo surgical specimens. Histopathologic grading of acute inflammation with the acute inflammatory score (AIS) (on the basis of mucosal ulceration, edema, and quantity and depth of neutrophilic infiltration) and the degree of fibrostenosis was performed at each site, and results were compared with MR imaging features. Data were analyzed by using linear regression with robust standard errors of the estimate. Results AIS was positively correlated with mural thickness and mural/CSF signal intensity ratio on T2-weighted fat-saturated images (P < .001 and P = .003, respectively) but not with mural enhancement at 30 and 70 seconds (P = .50 and P = .73, respectively). AIS was higher with layered mural enhancement (P < .001), a pattern also commonly associated with coexisting fibrostenosis (75%). Mural/CSF signal intensity ratio on T2-weighted fat-saturated images was higher in histologically edematous bowel than in nonedematous bowel (P = .04). There was no correlation between any lymph node characteristic and AIS. Conclusion Increasing mural thickness, high mural signal intensity on T2-weighted fat-saturated images, and a layered pattern of enhancement reflect histologic features of acute small-bowel inflammation in Crohn disease. Supplemental material: http://radiology.rsnajnls.org/cgi/content/full/radiol.2523082167/DC1 © RSNA, 2009
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