A Novel Labda‐7,13E‐dien‐15‐ol‐Producing Bifunctional Diterpene Synthase from Selaginella moellendorffii

Two-in-one enzyme: A bifunctional diterpene synthase from the lycophyte Selaginella moellendorffii has been characterized. The structure of its product, labda-7,13E-dien-15-ol, demonstrates that this enzyme catalyzes a novel class II diterpene cyclization reaction, and clarifies the biosynthetic origins of the family of derived natural products.