磷酰胺
寡核苷酸
寡核苷酸合成
单体
连接器
化学
氨基酸
群(周期表)
尿苷
基础(拓扑)
核酸
立体化学
组合化学
有机化学
生物化学
核糖核酸
聚合物
DNA
数学
基因
操作系统
数学分析
计算机科学
作者
Svetlana V. Vasilyeva,Tatyana V. Abramova,Vladimir N. Silnikov
标识
DOI:10.1081/ncn-200026053
摘要
A novel series of phosphoroamidites for the synthesis of 2-modified oligonucleotides was designed and synthesized on the base of 2'-amino uridine and 2'-amino arabinoadenosine. The amino groups in these compounds were acidified by bis-cyanomethyl esters of different dicarbonic acids. Generated reactive linker groups containing cyanomethoxycarbonyl groups are stable under conditions of oligonucleotide synthesis but could be easily functionalised in post-synthetic stage by treatment with compounds bearing primary amino groups.
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