接种疫苗
免疫原性
医学
病毒学
免疫系统
免疫学
材料科学
流感疫苗
作者
Sean P. Sullivan,Dimitrios G. Koutsonanos,M. Pino Martı́n,Jeong Woo Lee,Vladimir G. Zarnitsyn,Seong-O Choi,Niren Murthy,Richard W. Compans,Ioanna Skountzou,Mark R. Prausnitz
出处
期刊:Nature Medicine
[Springer Nature]
日期:2010-07-18
卷期号:16 (8): 915-920
被引量:746
摘要
Influenza prophylaxis would benefit from a vaccination method enabling simplified logistics and improved immunogenicity without the dangers posed by hypodermic needles. Here we introduce dissolving microneedle patches for influenza vaccination using a simple patch-based system that targets delivery to skin's antigen-presenting cells. Microneedles were fabricated using a biocompatible polymer encapsulating inactivated influenza virus vaccine for insertion and dissolution in the skin within minutes. Microneedle vaccination generated robust antibody and cellular immune responses in mice that provided complete protection against lethal challenge. Compared to conventional intramuscular injection, microneedle vaccination resulted in more efficient lung virus clearance and enhanced cellular recall responses after challenge. These results suggest that dissolving microneedle patches can provide a new technology for simpler and safer vaccination with improved immunogenicity that could facilitate increased vaccination coverage.
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