肢端肥大症
Pegvisomant公司
生长抑素
催乳素
内科学
内分泌学
腺瘤
垂体腺瘤
医学
生长细胞
增生
巨人症
生长抑素受体
垂体
病理
激素
生长激素
作者
Éva Horváth,Kálmán Kovács
出处
期刊:Neuroendocrinology
[S. Karger AG]
日期:2006-01-01
卷期号:83 (3-4): 161-165
被引量:53
摘要
This review summarizes current knowledge on pituitary changes in patients with acromegaly. The histologic, immunohistochemical and electron microscopic study provided conclusive evidence that a marked diversity exists between the tumors which secrete growth hormone (GH) in excess, such as densely and sparsely granulated GH cell adenoma, the mixed GH prolactin cell adenoma and the mammosomatotrope adenoma. The latter two tumors produce GH and prolactin simultaneously. Densely granulated GH cell tumors may produce thyrotropin and alpha subunit as well. Somatotrope carcinomas are extremely rare. GH cell hyperplasia can also be associated with acromegaly in patients with extrapituitary GH-releasing hormone secreting tumors. The medical therapy of acromegaly is reviewed briefly, including long-acting somatostatin analogs and pegvisomant, a GH receptor blocker.
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