白凤菜醇提物对非酒精性脂肪肝大鼠的治疗作用

Objective: To discuss the therapeutical effect of Gynura formosana (GF) alcohol extract on Non-alcoholic fatty liver disease induced by high-fat diet. Methods: The rat model was established by high fat diet,then rats were randomized into five groups, a normal control group,GF (low、middle and high dose) groups and a model control group.After four weeks with the treatment of GF alcohol extract ,the pathologic histology changes of liver tissue were observed. The levers of serum TG, TC, AST and ALT were detected. Results: Compared with the normal group, the content of serum TG,TC, AST and ALT in the model group is higher than in the normal group obviously ( P <0.05). The liver weight and visceral fat pad in the GF treatment group is significantly lower than the model group ( P <0.05) .In addition,GF can reduce the degree of liver steatosis and the levers of serum TG, TC, ALT and AST. Conclusion: GF has the rapeutical effect on Nonalcoholic fatty liver disease and could obviously improve blood lipid and hepatic steatosis of nonalcoholic fatty liver rats.