Objective:To analyze the value of CT perfusion and mammography in the diagnosis of breast diseases.Methods:45 patients with pathology proved breast disease were examined by mammography and CT perfusion,the imaging results were analyzed and correlated with pathology.Results:The diagnostic accuracy of mammography was 77.28%,CT perfusion was 88.89% and the diagnostic accuracy of mammography in combination with CT perfusion was 95.56%,significant statistical differences were existed (P0.05).The mean value of blood flow (BF),blood volume (BV) and surface permeability (PS) of breast malignancy on CT perfusion were markedly higher than that of benignancy.CT perfusion was superior to mammography in the diagnosis of extent of lesion and existence of necrosis (P0.05). Mammography was superior to CT perfusion in the identification of micro-calcifications (P0.05).Conclusion:The diagnostic accuracy of breast carcinoma could be improved by mammography in combination with CT perfusion.