Chemical Studies on Crude Drug Processing. II. Aconiti Tuber (1). : On the Constituents of "Chuan-wu", the Dried Tuber of Aconitum carmichaeli DEBX.

In the course of the chemical characterization of crude drug processing, the alkaloidal constituents of Aconiti Tuber ("chuan-wu", imported from Si Chuan, China), the dried tuber of Aconitum carmichaeli DEBX. were investigated. In addition to the known alkaloids such as aconitine (1), hypaconitine (2), mesaconitine (3), talatizamine (5), 14-acetyltalatizamine (6), isotalatizidine (7), karakoline (8), and neoline (9), four new lipo-alkaloids named lipoaconitine (10), lipohypaconitine (11), lipomesaconitine (12), and lipodeoxyaconitine (13), were isolated and their structures elucidated. It was also found that the acetyl functions attached to the C-8 hydroxyls of 1, 2, and 3 were readily interchanged by the fatty acid residues.