酪氨酸磷酸化
转录因子
生物
分子生物学
受体酪氨酸激酶
磷酸化
细胞生物学
酪氨酸激酶
Sp3转录因子
化学
生物化学
信号转导
基因
增强子
作者
Christian Schindler,Ke Shuai,Vincent R. Prezioso,James Darnell
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1992-08-07
卷期号:257 (5071): 809-813
被引量:850
标识
DOI:10.1126/science.1496401
摘要
The interferon-α (IFN-α)-stimulated gene factor 3 (ISGF3), a transcriptional activator, contains three proteins, termed ISGF3α proteins, that reside in the cell cytoplasm until they are activated in response to IFN-α. Treatment of cells with IFN-α caused these three proteins to be phosphorylated on tyrosine and to translocate to the cell nucleus where they stimulate transcription through binding to IFN-α-stimulated response elements in DNA. IFN-γ, which activates transcription through a different receptor and different DNA binding sites, also caused tyrosine phosphorylation of one of these proteins. The ISGF3α proteins may be substrates for one or more kinases activated by ligand binding to the cell surface and may link occupation of a specific polypeptide receptor with activation of transcription of a set of specific genes.
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