Prevention of radiation-induced chromosome damage in mouse bone marrow by aqueous leaf extract of Chicorium intybus

The radioprotective effect of aqueous leaf extract of Chicorium intybus (Chicory) against radiation induced chromosomal damage was investigated. Adult Swiss albino mice were exposed to 4 Gy 60Co γ-rays. Aqueous extract (50 and 100 mg/kg body wt) was administered orally just after irradiation. Bone marrow protection was evaluated by scoring the different types of individual aberrations and aberrant metaphases, 24hrs after irradiation. Significant reduction in number of aberrant cells and different type of aberrations was observed in treated group compared to irradiated untreated group of animals. The administration of aqueous leaf extract of Chicory to the animals showed significant reduction in micronucleus induction. The extract also possessed significant hydroxyl radical scavenging activity. The effectiveness of the drug to prevent chromosomal damage consequent to irradiation along with its high solubility in water, favor its application, in accidental radiation exposures and nuclear accidents. Key Words: Chromosomal aberration, micronucleus, C. intybus, aqueous extract. Chicorium intybus sulu yaprak ekstreleri ile fare kemik iliÛinde radyasyon nedenli kromozomal hasarÝn nlenmesi zet Bu alÝßmada Chicorium intybusÕun (Chicory) sulu yaprak ekstrelerinin, radyasyon sonucu olußturulan kromozomal