Vitamin B1 suppresses liver cancer growth and restores tumor microcirculation

, VitB1 suppressed liver cancer growth in a dose-dependent manner. High- and medium-dose VitB1 treatment increased microvascular blood perfusion and flow velocity assessed using a laser Doppler flowmetry (LDF) system and decreased tumor microvessel density, without affecting tumor microvascular red blood cell concentration. Moreover, high- and medium-dose VitB1 significantly increased the amplitudes of the neurogenic and endothelial oscillatory components of blood perfusion and flow velocity. These findings suggest that the anti-tumor effects of VitB1 may involve the modulation of neurogenic and endothelial activity, which is associated with improved tumor microhemodynamics. Further studies are needed to elucidate the precise mechanisms and the interplay between direct tumor cell effects and microcirculatory changes.