抗菌剂
抗生素耐药性
抗菌药物
鉴定(生物学)
生物
专家意见
抗药性
组学
生物技术
药物发现
计算生物学
数据科学
生物信息学
医学
抗生素
微生物学
计算机科学
重症监护医学
植物
作者
В. М. Чернов,О. А. Чернова,Alexey A. Mouzykantov,Leonid Lopukhov,Rustam Aminov
标识
DOI:10.1080/17460441.2019.1588880
摘要
Introduction: The development of new antimicrobials has become an urgent priority because of a global challenge emerging from the rise of antimicrobial resistant pathogens.Areas covered: In this review, the authors discuss the opportunities offered by modern omics approaches to address the challenge and the use of this approach in antimicrobial development. Specifically, the authors focus on the role of omics technologies and bioinformatics for the revelation of the effects of antimicrobials in a variety of microbial cellular processes, as well as the identification of potential cellular targets, the mechanisms of antimicrobial resistance, and the development of new antimicrobials.Expert opinion: Prevention of antimicrobial resistance does not only depend on rational drug design such as narrow-spectrum antimicrobials but on several factors. It is the opinion of the authors that the use of a multi-omics bioinformatics approach should become an integral part of antimicrobial drug discovery as well as in the prevention of antimicrobial resistance.
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