组织工程
体内
生物医学工程
生物反应器
计算机科学
骨组织
生物
医学
生物技术
植物
作者
Banu Akar,Alexander M. Tatara,Alok Sutradhar,Hui‐Yi Hsiao,Michael J. Miller,Ming‐Huei Cheng,Antonios G. Mikos,Eric M. Brey
出处
期刊:Tissue Engineering Part B-reviews
[Mary Ann Liebert]
日期:2018-08-01
卷期号:24 (4): 317-325
被引量:22
标识
DOI:10.1089/ten.teb.2018.0005
摘要
Reconstruction of large skeletal defects is challenging due to the requirement for large volumes of donor tissue and the often complex surgical procedures. Tissue engineering has the potential to serve as a new source of tissue for bone reconstruction, but current techniques are often limited in regards to the size and complexity of tissue that can be formed. Building tissue using an in vivo bioreactor approach may enable the production of appropriate amounts of specialized tissue, while reducing issues of donor site morbidity and infection. Large animals are required to screen and optimize new strategies for growing clinically appropriate volumes of tissues in vivo. In this article, we review both ovine and porcine models that serve as models of the technique proposed for clinical engineering of bone tissue in vivo. Recent findings are discussed with these systems, as well as description of next steps required for using these models, to develop clinically applicable tissue engineering applications.
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